Publications

Pancreatic Cancer Development and Progression

Cell (2019): Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer
Ligorio M*,Srinjoy Sil, Lopez Jose-Malagon, Linda T. Nieman, Misale S, Di Pilato M, Richard Y. Ebright, Karabacak M, Kulkarni A, Rajurkar M, , Boukhali M, Fatherree J, Tai E, D. Vo KD, Damon LJ, Xega K, Desai R, Choz M, Bersani F, Thapar V, Rivera M, … , Fernandez-Del Castillo C, Ferrone CR, Haas W, Aryee M, Ting D.

PNAS (2019): Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma.
Porter RL, Magnus NKC, Thapar V, Morris R, Szabolcs A, Neyaz A, Kulkarni AS, Tai E, Chougule A, Hillis A, Golczer G, Guo H, Yamada T, Kurokawa T, Yashaswini C, Ligorio M , Vo KD, Nieman L, Liss AS, Deshpande V, Lawrence MS, Maheswaran S, Fernandez-Del Castillo C, Hong TS, Ryan DP, O’Dwyer PJ, Drebin JA, Ferrone CR, Haber DA, Ting DT.

Science (2017): Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine
Geller L T, Barzily-Rokni M, Danino T, Jonas O H, Shental N, Nejman D, Gavert N, Zwang Y, Cooper Z A, Shee K, Thaiss C A, Reuben A, Livny J, Avraham R, Frederick D T, Ligorio M, Chatman K, Johnston S E, Mosher C M, Brandis A, Fuks G, Gurbatri C, Gopalakrishnan V, Kim M, Hurd M, Katz M, Fleming J, Maitra A, … , Huttenhower C, Bhatia S N, Gevers D, Wargo J A, Golub T R, Straussman R.

Nature (2013): Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, DePinho RA, Cantley LC, Kimmelman AC.

Characterization of Circulating Tumor Cells (CTCs)

Nat. Commun. (2020): Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target.
Franses JW, Philipp J, Missios P, Bhan I, Liu A, Yashaswini C, Tai E, Zhu H, Ligorio M, Nicholson B, Tassoni EM, Desai N, Kulkarni AS, Szabolcs A, Hong TS, Liss AS, Fernandez-Del Castillo C, Ryan DP, Maheswaran S, Haber DA, Daley GQ, Ting DT.

Nature (2016): Heterogeneity of HER2 expression in circulating breast cancer cells identifies functionally distinct populations.
Vincent N, Bardia A, Wittner B, Benes C, Ligorio M, Zheng Y, Yu M, Sundaresan T, Desai R, O’Keefe R, Ebright R, Boukhali M, Sil S, Kapur R, Sgroi D, Ting D, Toner M, Ramaswamy S, Haas W, Maheswaran S, Haber D.

Cell Rep. (2014): Single Cell RNA-sequencing Identifies Extracellular Matrix Gene Expression by Pancreatic Circulating Tumor Cells.
Ting D, Wittner B, Ligorio M, Vincent Jordan N, Shah A, Miyamoto D, Aceto N, Bersani F, Brannigan B, Xega K, Ciciliano J, Zhu H, MacKenzie O, Trautwein J, Arora K, Shahid M, Ellis H, Qu N, Bardeesy N, Rivera M, Deshpande V, Ferrone C, Kapur R, Ramaswamy S, Shioda T, Toner M, Maheswaran S, Haber D.

Novel Biomarkers

Ann Surg Oncol (2016): Phosphorylated histone H3 (PHH3) is a superior proliferation marker for prognosis of pancreatic neuroendocrine tumors.
Villani* V, Mahadevan* K, Ligorio* M , Fernandez-del Castillo C, Ting D, Sabbatino F, Zhang I, Vangel M, Ferrone S, Warshaw A, Lillemoe K, Wargo J, Deshpande V, Ferrone C.

J Gastrointest Surg (2012): Superior prognostic importance of perineural invasion vs. lymph node involvement after curative resection of duodenal adenocarcinoma.
Cecchini S, Correa-Gallego C, Desphande V, Ligorio M , Dursun A, Wargo J, Fernàndez-del Castillo C, Warshaw AL, Ferrone CR.

Improving Surgical Outcomes

Dis Colon Rectum (2009): The impact of stapled transanal rectal resection on anorectal function in patients with obstructed defecation syndrome.
Reboa G, Gipponi M, Ligorio M , Marino P, Lantieri F.

In Vivo (2007): Clinical applications of autologous cryoplatelet gel for the reconstruction of the maxillary sinus. A new approach for the treatment of chronic oro-sinusal fistula
Scala M, Gipponi M, Pasetti S, Dellachá E, Ligorio M, Villa G, Margarino G, Giannini G, Strada P.

Patent Technology

Biomaterials (2016): A Tunable Delivery Platform to Provide Local Chemotherapy for Pancreatic Ductal Adenocarcinoma.
Indolfi* L, Ligorio* M, Ting* D, Bersani F, Aceto N, Deshpande V, Ferrone C, Haber D, Langer R, Clark J, Edelman E.

Patent Application US 14/250,025 (2014): Local drug delivery devices and methods for treating cancer.
Indolfi L, Edelman ER, Langer RS, Clark JW, Ting DT, Ferrone CRA, and Ligorio M